1:
The ideal Google AdSense page should have grand content about a very distinct topic. Take pains to be very clear about what the topic is, and carefully choose the keyword (or key phrase) describing the topic. Users do not like vague pages that dont generate it very clear what the page is all about.

Do not even ponder trying to trick AdSense. (They have penalties, including acquiring kicked out.) Dont create a page on one topic and give it a document title about a different topicthats too confusing.

In a nutshell, you want to make sure the page you create offers grand assessment of worth to many people interested in the topic. When you provide excellent experience on a explicit topic, your visitors will benefit and will be more likely to click through to relevant AdWords.

2:
Everyones seen way too many horizontal banner ads up top. Thus, Google recommends you choose the vertical -- not horizontal -- format to display your AdWords. I agree. People have become "banner blind" to a horizontal format. Plus, Google has "trained" us to click on relevant text ads on their own page and they utilize the vertical format.

3:
Its to your financial advantage to put the AdWords near the top of your page on the right. Make sure there is enough "breathing room" -- i.e. white space around the ads -- so that they will easily attract your visitors.

4:
The latest branding tests have revealed that posting pictures beside, or above youre a ads might have a massive impact on click-thru rates. This is because the eye is immediately attracted to the picture, once they see the picture, they see the advertisement !

5:
I understand its tempting, because it seems so brain friendly and its just sitting there standing around for you to do it, but do not click on the AdWords displayed on your own site to increase your revenue. Google (rightfully) frowns on this.

Plus, Google has some of the smartest engineers around, and they are very dazzling at detecting this kind of fraud. And really, for an extra $1, is it value grasping kicked out of a money-maker like AdSense? I think not